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Wuhan Hengwo Scien-Tech Co., Ltd.

Agomelatine, Nootropic, Pharmaceutical Chemical manufacturer / supplier in China, offering Nootropic Supplement Antidepressant Drugs Agomelatine with High Quality, High Quality Sarm Andarine S-4 for Fat Loss, Fine Sarm Ibutamoren Mk-677 for Fat Loss and Muscle Gain and so on.

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Nootropic Supplement Antidepressant Drugs Agomelatine with High Quality

Purchase Qty.:
(g)
1-9 10+
FOB Unit Price: US $2 US $1.7
Purchase Qty. (g) FOB Unit Price
1-9 US $2
10+ US $1.7
Get Latest Price
Port: Hong Kong, Hong Kong
Production Capacity: 500kg/Month
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: CAS 138112-76-2
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • CAS No.: 138112-76-2
  • MP: 107-109°c
  • Usage: Supplement
  • Transport Package: Disguised Packing for Delivery Guarantee!
  • Origin: China
  • Powder: Yes
  • Certification: GMP, ISO 9001
  • State: Solid
  • Product Name: Agomelatine
  • Molecular Formula: C12h18n4o5s
  • Appearance: White Powder
  • Trademark: Biopharmchem
  • Specification: Pharmaceutical Grade
  • HS Code: 2937290090
Product Description
Nootropic Supplement Antidepressant Drugs Agomelatine With High Quality

Quick Detail
 
Product NameAgomelatine
CAS138112-76-2
MFC12H18N4O5S
MW330.3601
Purity99%
MP107-109°C
GradePharmaceutical Grade
AppearanceWhite Powder

Description

Agomelatine is a melatonergic antidepressant developed by the pharmaceutical company Servier. It is the world's first melatonin receptors MT1 and MT2 agonist class of antidepressants. It applies to the treatment of adult patients with severe depressive. Since that melatonin has high catabolism rate in vivo which mikes its half-life shorter and the selectivity of its receptor located in the SCN poorer, the treatment of circadian rhythms disorders is limited. Indole ring of melatonin is the structure sites of catabolic inactivation.

Agomelatine developed by Servier company is melatonin's naphthalene biological (electronic) isostere analogs. Indole ring is substituted by naphthalene nucleus, which leads it have more metabolic stability than melatonin.

Due to its distinctive mechanism of action, agomelatine is also studied for its effects on sleep regulation. Studies report various improvements in general quality of sleep metrics, as well as specific therapeutic benefits in circadian rhythm disorders.

Nootropic Supplement Antidepressant Drugs Agomelatine with High Quality

Mechanism of Action

Agomelatine is melatonin MT1/MT2 receptor agonist and serotonin 2c (5-HT2C) receptor antagonist. It can make depressed patients' biological rhythm disorders return to normal through the synergy between the two and then result in antidepressant efficacy. Its unique mechanism of action has opened up an innovative way to treat depression. 

Agomelatine's mechanism of drug action is completely different with antidepressants that are commonly used today, such as selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI). The molecular structure of agomelatine directly combines with serotonin 2c (5HT2c) receptor of post-synaptic membrane so as to exert its antidepressant efficacy without increasing serotonin concentration in the synaptic cleft. This unique mechanism of action makes agomelatine quickly and effectively exert its antidepressant efficacy at the same time, and avoid the occurrence of adverse drug reactions to an extreme.

Another unique targets of agomelatine is in melatonin receptors. MT1 and MT2 receptors densely distribute in the human suprachiasmatic nucleus. The nucleus mainly control human sleep rhythm. Agomelatine can well improve the quality of patients' sleep by agonism on MT1 MT2 receptors, and improve patients' wakefulness during the day. The quality of sleep has both cause and effect relationship with depression outcomes state. It is reported that 80% of patients with depression have the problems of sleep disorders at different levels. The improvement of sleep quality can directly contribute to the improvement of the overall clinical condition of patients with depression.

Our Advantages

1. Competitive prices: For small order and bulk purchase, the price will be different. A good discount would be given when you make a large order, we usually send extra powders as gift to our customers.

2. Top quality: With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market and the requirements of customers. All of our products are highly quality guaranteed, once any problem is found, the package would be reshipped for you.

3. Discreet package: All orders are packed the way suits you best to cross customs safely. Since this is related to size and value of your order, it may come in more than one package. Or if you have your own ideal way, it could be also taken into consideration.

4. Security Shipping: We'd like to send by different express(UPS,DHL,TNT,EMS,FedEx,Hongkong Post) at one period of time. The most professional forwarder would be recommanded for you.

5. Fast delivery: We have stock, so we can delivery quickly once payment is received.

6. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East and so many other countries, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

7. Best service: We will give you warm after-sale service, any of your question would be solved as soon as possible.

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