High Purity Nicotinamide as Food Additive Vitamin B3
|FOB Unit Price:||US $1 US $0.78|
|Purchase Qty. (g)||FOB Unit Price|
|Port:||Hong Kong, Hong Kong|
|Production Capacity:||2000 Tons/Year|
|Payment Terms:||T/T, Western Union, Money Gram, Bitcoin|
- Model NO.: Vitamin B3
- Customized: Customized
- Suitable for: Adult
- Purity: >99%
- Alias: Vitamin B3
- Einecs No: 202-713-4
- Molecular Weight: 122.12
- Trademark: Biopharmchem
- Specification: USD Standard
- HS Code: 3001200010
- Powder: Yes
- Certification: GMP, HSE, ISO 9001
- State: Solid
- Product Name: Vitamin B3
- CAS Registry Number: 98-92-0
- Molecular Formula: C6h6n2o
- Appearance: White Powder
- Transport Package: 1 Kg/Foil Bag
- Origin: Hubei, China
Product Name: Nicotinamide
Synonyms: 3-PYRIDINECARBOXAMIDE;3-PYRIDINE CARBOXYLIC ACID AMIDE;3-PYRIDINECARBOXYLIC AMIDE;TIMTEC-BB SBB004283;NICETHAMIDUM;NIACINAMIDE;NICOTINIC ACID AMIDE;NICOTINAMIDE
Product Categories: Biochemistry;Vitamins;Nutritional Supplements;Vitamins and derivatives;Vitamin Ingredients;Miscellaneous Compounds;Aromatics;Nicotine Derivatives;Vitamin series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;vitamin;Other APIs;Cosmetics;food additive;Cosmeitc raw materials;Inhibitors
Mol File: 98-92-0.mol
Vitamin nicotinamide also called nicotinamide, vitamin B3 or vitamin PP is a water-soluble vitamin, a B vitamin, as NAD (nicotinamide adenine dinucleotide, NAD) and NADP (nicotinamide adenine dinucleotide phosphate, NADP) composition, hydrogenation and dehydrogenation properties of nicotinamide in the body of the two part coenzyme structure have reversible, in biological oxidation plays a role of hydrogen delivery, can promote tissue respiration, biological oxidation process and The new supersedes the old. in maintaining normal tissue, especially the skin, digestive and nervous system plays an important role in the integrity of the system. Due to the lack of time, respiration and metabolism of cells affected by pellagra, this product is mainly used for prevention and treatment of pellagra, stomatitis, glossitis etc.. In addition, this product has the effect of preventing cardiac block and improving the function of sinoatrial node and anti fast experimental arrhythmia. It can significantly improve the heart rate slowing and atrioventricular block caused by Vera Pammy. Clinical for coronary heart disease, viral myocarditis, rheumatic heart disease and a handful of digitalis poisoning associated with arrhythmia (mostly applied only when other medications fail), generally the degree atrioventricular block has obvious curative effect, basically after the treatment, block can disappear in sick sinus syndrome also has the obvious curative effect, the poor effect of bundle branch block. This product orally absorbed by the stomach intestine, intramuscular absorption faster, absorbed and distributed to all tissues of the body, t1/2 for 45 minutes. The metabolism of the liver, most of the generation Xie N- methyl nicotinamide, the amount of treatment is only a small amount of urine excreted in the prototype, the dosage exceeds the need for increased excretion. If the daily urine N- nicotinamide is lower than 4mg, suggesting nicotinamide deficiency.
Nicotinamide and niacin are collectively referred to as vitamin PP, niacin in animals in the form of nicotinamide involved in metabolic processes, both have a common vitamin activity. For white crystalline powder, odorless or almost odorless, bitter taste. Soluble in water or ethanol; soluble in glycerol. Having a weak moisture absorption. More stable, acid, alkali and high temperature. Nature is mainly found in cereals, yeasts, peanuts, meat, animal organs, offal, milk and green leafy vegetables, but tryptophan can be synthesized in human bodies, but the efficiency is very low. E. coli (Escherichia, coli) in the intestinal tract can synthesize nicotinic acid and convert it into nicotinamide. Prevention and treatment of pellagra, exposed parts of symmetric dermatitis, stomatitis, glossitis, anorexia, dermatitis, liver disease, coronary heart disease, atrioventricular block and sick sinus syndrome, diarrhea, neuritis and dementia.
[adverse reactions] occasionally dizziness, nausea, epigastric discomfort, loss of appetite and so on, can disappear on its own, in the early pregnancy overdose, teratogenic may be, intramuscular injection can cause pain, it is less used.
Chemical properties of white acicular crystalline or crystalline powder, odorless or slightly smelly, slightly bitter taste. The relative density is 1.4 and the melting point is 129-131. 1g this product is soluble in 1mL water, 1.5mL ethanol or 10mL glycerin, insoluble in ether. PH of 10% aqueous solution is 6.5-7.5. In dry air, both light and heat are stable, and nicotinic acid is produced when heated in an alkaline or acidic solution. The ADI values of rats were not specified by mouth LD502.5-3.5g/kg (ECC, 1990)
The use is the same as niacin. Water solubility is better than niacin, but easy to produce complex with vitamin C and caking. Dosage 30-80mg/kg.
The use of nicotinamide and niacin is common in most sounds and nicotinic acid also produces nicotinamide in animals. Lack of nicotinic acid and nicotinamide, will have pellagra. So they can prevent pellagra. They play a role in the metabolism of proteins and sugars and can improve the nutrition of humans and animals. In addition to being used in medicine, it is also widely used as food and feed additives. The world's production capacity has exceeded 30 thousand tons. In Japan, nicotinamide used in medicine accounted for 40%, feed additives accounted for 50%. Food additives accounted for 10%. Nicotinic acid and nicotinamide are non-toxic in nature and are more common in animal liver, kidney, yeast and rice sugar, and nicotinamide is subcutaneously injected with LD50 of 1.7 g / kg in rats.
Use of vitamin medicine, participated in metabolism, for the prevention and treatment of pellagra, niacin deficiency
Use for skin care products, can prevent rough skin, maintain skin cell health, promote skin whitening. Used in hair care, can promote the blood circulation of the scalp, healthy hair follicles, promote hair growth, prevent baldness
Study on the use of biochemical nutrients; tissue culture; clinical medicine for vitamin B, for prevention and treatment of pellagra and stomatitis, glossitis and other diseases.
Biochemical research. Prepared tissue culture medium. Pharmaceutical industry
An amide derivative of vitamin B3 and PARP inhibitors