Anti Estrogen Steroids Breast Cancer Treatment Steroids Trilostane
|FOB Unit Price:||US $1 US $0.78|
|Purchase Qty. (g)||FOB Unit Price|
|Production Capacity:||2 Tons/Year|
|Transport Package:||1 Kg/Foil Bag|
|Payment Terms:||T/T, Western Union, Money Gram, Bitcoin|
- Model NO.: Trilostane
- Customized: Customized
- Suitable for: Adult
- Purity: >99%
- Alias: Trilostane
- Einecs No: 237-133-0
- Molecular Weight: 329.43
- Trademark: YC
- Origin: Hubei, China
- Powder: Yes
- Certification: GMP, HSE, ISO 9001
- State: Solid
- Product Name: Trilostane
- CAS Registry Number: 13647-35-3
- Molecular Formula: C20h27no3
- Appearance: White Powder
- Specification: USD Standard
- HS Code: 3001200010
Product Name: Trilostane
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Inhibitor;FULVICIN
Mol File: 13647-35-3.mol
Be in Los Tanzania can inhibit glucocorticoid in the synthesis process of 3 beta dehydrogenase, the cortisol and aldosterone synthesis decreased, clinical for the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism, but the treatment of Cushing syndrome (hypercortisolism) as the curative effect of metyrapone. This product also has a significant effect on lowering blood testosterone levels, which may be related to the inhibition of its synthesis.
Song is the 4 Los treatment history Tanzania alpha, 5 alpha cyano - -2- epoxy androst -2- ene -3,17 beta diol, reversibly inhibited in the adrenal cortex of 3 beta hydroxy steroid dehydrogenase and 5,4- delta isomerase, which block the biosynthesis of mineralocorticoid and glucocorticoid, received treatment of aldosterone over 1980 many disease and hypercortisolism in Britain in 1985 allowed the treatment of Cushing's syndrome is hyperadrenocorticism in the United states. Since older animals, especially elderly dogs, are susceptible to Cushing's syndrome, which can relieve the symptoms of more than 90% of dogs and improve their quality of life, the drug is also approved for veterinary use in the uk. In its own absence of hormonal activity, it has less side effects, and is particularly safe and well tolerated.
The mechanism of action is that breast cancer is a hormone dependent tumor, while estrogen is the major driving factor for the growth of this cancer cell. Therefore, one of the major modern therapies for breast cancer is targeted estrogen, which blocks estrogen production or blocks estrogen at its site of action, the estrogen receptor. It has been assumed that estrogen receptors are only single receptors, but recent studies have identified that there are at least two subtypes of alpha and beta. Estrogen, in combination with estrogen receptor alpha, can stimulate cell growth, but in combination with the beta estrogen receptor, it can down regulate alpha estrogen receptors and slow down the rate of cell proliferation. The research reveals that Qu Tan Los could not only reduced estrogen production, can also be combined with the regulation of estrogen in different subtypes of estrogen receptor, and estrogen receptor alpha showed dual effects of inhibitors and beta estrogen receptor agonists, negative affect the final arrest and change of estrogen on cancer cells. The mode of action of Qu Tan Los unique not only make it different from other existing anti estrogen drugs, but also to the other anti estrogen therapy treatment failure or drug resistant breast cancer remains highly effective pharmacological basis.
Chemical Properties Tan Crystals
Usage An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer
Usage antifungal, inhibits mitosis in metaphase
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