USP Grade Min High Quality Pharmaceuticals and Nutraceuticals L-Tyrosine
|FOB Unit Price:||US $1 US $0.78|
|Purchase Qty. (g)||FOB Unit Price|
|Production Capacity:||2 000tons/Year|
|Transport Package:||1 Kg/Foil Bag|
|Payment Terms:||T/T, Western Union, Money Gram, Bitcoin|
- Model NO.: L-Tyrosine
- Customized: Customized
- Suitable for: Adult
- Purity: >99%
- Alias: L-Tyrosine
- Einecs No: 200-460-4
- Molecular Weight: 181.19
- Trademark: YC
- Origin: Hubei, China
- Powder: Yes
- Certification: GMP, HSE, ISO 9001
- State: Solid
- Product Name: L-Tyrosine
- CAS Registry Number: 60-18-4
- Molecular Formula: C9h11no3
- Appearance: White Powder
- Specification: USD Standard
- HS Code: 3001200010
Product Name: L-Tyrosine
Synonyms: 3-(4-HYDROXYPHENYL)-L-ALANINE;2-Amino-3-(4-hydroxyphenyl)-propanoic acid;2-AMINO-3-(P-HYDROXYPHENYL)PROPIONIC ACID;4-HYDROXYPHENYLALANINE;FEMA 3736;H-L-TYR-OH;H-TYR-OH;L-3-[4-HYDROXYPHENYL]ALANINE
Product Categories: Food and Feed Additive;Tyrosine [Tyr, Y];Amino Acids;Amino Acids and Derivatives;alpha-Amino Acids;Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids;NORCURON;amino;Inhibitors
Mol File: 60-18-4.mol
Tyrosine in human metabolism Tyrosine is an amino acid building blocks of proteins, and having a side chain having an aromatic ring of ionization, is addicted to the aqueous, tyrosine in the human and animal bodies is generated by the hydroxylation of phenylalanine, so when phenylalanine nutrition is adequate, it is non essential amino acid.
Catabolism of tyrosine is firstly catalyzed by tyrosine aminotransferase in the liver , then transform into hydroxyphenyl pyruvate, the enzyme needs coenzyme pyridoxal phosphate . Hydroxyphenyl pyruvate by hydroxyl phenylketonuria hydroxylase role, while oxidative decarboxylation and metastasis, and the benzene ring ortho hydroxylation of the side chain of pyruvate to generate the urine black acid (glyoxylic acid). The enzyme is a protein containing copper metal, needing ascorbic acid and coenzyme consume molecular oxygen. Black acid in urine in the urine black acid dioxygenase (urine black acid oxidase) catalyzes the cleavage benzene to produce maleic acid acetoacetate; enzyme is a protein ferrous metals, the reactions require oxygen molecule to be involved in . Maleic acid via the corresponding acetoacetate isomerase role into fumarylacetoacetate need coenzyme glutathione. Finally, from the corresponding hydrolase hydrolyzed as fumaric acid and acetyl acid, so tyrosine is both glycogeneticr and ketogenic amino acids.
tyrosine kinase tyrosine kinase , enzyme catalytic in peptide chain tyrosine residue (loci) phosphorylated,plays an important role in biological metabolism and cell communication, and molecular weight of 56,000, endometrial bound enzyme. The enzyme consists of two domains, a catalytic domain, accounting for most of the enzyme molecules, which contains two tyrosine phosphorylation sites and a C-terminal ; the other is the regulatory domain (i.e. SH2 domain), containing the N-terminal myristoylation, serine phosphorylation site and homologous regions.
Tyrosine phosphorylation sites of the catalytic domain shows a great relation to tyrosine kinase activity , if these sites are phosphorylated, tyrosinekinase activity would be inhibited; on the contrary, if the phosphorylation of tyrosyl acid sites with phosphatase to dephosphorylate, the kinase activity can be significantly increased. Tyrosine phosphorylation sites near the ends of the C, but with different tyrosine kinase gene expression (e.g., c-src gene product family), the location of these sites is different, if it is missing out, it kinases is Activated. In addition, the polyomavirus middle T-antigen gene expression and c-src tyrosine kinase binding sites in the vicinity of 527 tyrosine at the site, since it is too close to this site , the formation of a steric hinders the phosphorylation site, it increases the kinase activity.
SH2 domain in addition to homologous regions , other parts are of the large differences in structure, so it is possible to act with different regulating factors, plays a role in regulating the kinase activity.
hemical Properties White needle crystal or crystalline powder, odorless, bitter taste, mp334 ºC (decomposition) is insoluble in water (0.04%, 25 ºC), insoluble in ethanol, ether and acetone, soluble in dilute acid or base . The isoelectric point of 5.66.
Uses For biochemical research,it is used as amino acids nutritional in medicine for the treatment of polio, encephalitis, hyperthyroidism and other diseases.
Nutritional supplements. for the manufacture of L-dopa diiodo tyrosine. After aminocarbonyl hot reaction with sugars, it can generate a special flavor substances.
For tissue culture (L-tyrosine· 2Na· H2O), biochemical reagents, treatment of hyperthyroidism. Also available as modulation for rhe eldee, children's food and nutrition agents of plant leaves.
Production Method after precipitation of the casein, silk and other protein acid hydrolyzates,dissolve in dilute aqueous ammonia, with acetic acid neutralize to pH = 5, recrystallization to derive it. Extract The pig hydrolyzate to get second crude liquid crystalline pure cystine, store two days at 20 ºC, tyrosine precipitation, filtration, available tyrosine crude, refine also to receive L-Tyrosine . 1% Of pig yield.
Casein as raw materials, reflux for several in hourshydrochloric acid , filter, and concentrate, soda and charcoal, crystallize,obtain products.
Production of L-Tyrosine mainly takes proteolysis extraction. blood meal, hoof angle, silk and other raw materials, acid hydrolysis, separation and purification.
Blood meal [HCl (hydrolysis)] → [110 ºC, 24h] hydrolyzate [rush acid] → [concentrated by evaporation] In addition to the acid [charcoal] → destaining solution [bleaching, cooling and crystallization] → L-Tyrosine crude [Activated Carbon (refined)] → [90 ºC, 30min] filtrate [crystalline] → L-tyrosine.
Hydrolysis, rush acid the blood meal, water, industrial hydrochloric as 1: 1.3: 1 ratio by weight, respectively put into the hydrolyzed cylinder, heat to 112-114 ºC, stop after 24h of stirring under reflux , cool and filter to remove, give filtrate which is hydrolyzate . The hydrolyzate is concentrated by evaporation to a syrup, add water to dissolve ,oncentrated by evaporation, so repeat three times to rush the acid.
Bleaching, crystallized concentrate is diluted with distilled water to the whole solution,add aqueous ammonia solution to pH 3.5, 1% charcoal is added, boiling with stirring 10min, stirring in a water bath at 90 ºC incubated 30min, filter while hot, active carbon layer is washed with distilled water 3 times, and the filtrate and washings are combined. According to the Act, continue to use active carbon to make the solution pale yellow. The filtrate is placed in quiet place below 10 ºC 24h, ie, crystalline precipitation, filtration to obtain crude L-tyrosine.
Recrystallized tyrosine crude 1:20 distilled water is added, after the whole solution, plus 1% activated carbon, 90 ºC insulation mixing 30min, filter hot and the filtrate cool to refined crystallize . The crystals are collected by filtration, washed with anhydrous ethanol twice, 60 ºC drying, the finished product is L-tyrosine.
Chemical Properties White to off-white powder
Usage neuromuscular blocker
Usage L-Tyrosine is one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.
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