Gold Member Since 2016
Wuhan Hengwo Scien-Tech Co., Ltd.

Gabapentin, Gabapentin HCl, Steroid Hormone manufacturer / supplier in China, offering Gabapentin HCl Anticonvulsant and Analgesic Drug Gabapentin Hydrochloride, Natural Plant 99% Min Extract Silymarin CAS 65666-07-1, High Purity Anabolic Steroid Hormone Powder Drostanolone Propionate Masteron and so on.

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Supplier Homepage Product Pharmaceutical APIs Gabapentin HCl Anticonvulsant and Analgesic Drug Gabapentin Hydrochloride

Gabapentin HCl Anticonvulsant and Analgesic Drug Gabapentin Hydrochloride

Purchase Qty.:
(g)
10-99 100+
FOB Unit Price: US $1 US $0.78
Purchase Qty. (g) FOB Unit Price
10-99 US $1
100+ US $0.78
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Port: Hong Kong, Hong Kong
Production Capacity: 2000 Tons/Year
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: Gabapentin
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • Alias: Gabapentin HCl; Gabapentin (Hydrochloride)
  • Einecs No: 262-076-3
  • Molecular Weight: 171.24
  • Grade: Pharmaceutical Grade
  • Transport Package: 1 Kg/Foil Bag
  • Origin: Hubei, China
  • Powder: Yes
  • Certification: GMP, HSE, ISO 9001
  • State: Solid
  • Product Name: Gabapentin Hydrochloride
  • CAS Registry Number: 60142-96-3
  • Molecular Formula: C9h17no2
  • Appearance: White Powder
  • Trademark: Biopharmchem
  • Specification: USD Standard
  • HS Code: 3001200010
Product Description
Gabapentin HCl Anticonvulsant and Analgesic Drug Gabapentin Hydrochloride
 
Product NameGabapentin hydrochloride
AliasGabapentin HCl; Gabapentin (hydrochloride); 2-(1-(aminomethyl)cyclohexyl)acetic acid hydrochloride
CAS Registry Number60142-96-3 
Einecs No262-076-3
Molecular FormulaC9H17NO2
Molecular Weight171.24
Purity99%
GradePharmaceutical Grade
Appearancewhite crytalline powder

Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain. IC50 Value: 140 nM (α2δ subunit of calcium channel) 

[1] Target: Calcium Channel in vitro: Gabapentin, baclofen and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid (IC50=20 microM, 0.8 microM and 2 microM, respectively). Gabapentin was without effect on the release of [3H]GABA, whilst baclofen (IC50=8 microM) and CGP 44532 (IC50=1 microM) inhibited [3H]GABA release 

[2]. A large inhibition of calcium currents by gabapentin was observed in pyramidal neocortical cells (up to 34%). Significantly, the gabapentin-mediated inhibition of calcium currents saturated at particularly low concentrations (around 10 microM), at least in neocortical neurons (IC50 about 4 microM)

[3]. in vivo: Gabapentin produced an anti-allodynic effect over the 7-day period, reducing the expression of pro-inflammatory cytokines but increasing the expression of IL-10 (TNF-α, 316.0 ± 69.7 pg/mL vs 88.8 ± 24.4 pg/mL; IL-1β, 1,212.9 ± 104.5 vs 577.4 ± 97.1 pg/mL; IL-6, 254.0 ± 64.8 pg/mL vs 125.5 ± 44.1 pg/mL; IL-10, 532.1 ± 78.7 pg/mL vs 918.9 ± 63.1 pg/mL). The suppressive effect of gabapentin on pro-inflammatory cytokine expression was partially blocked by the anti-IL-10 antibody [4]. Toxicity: No new safety signals or adverse event trends relating to GEn exposure were identified [5]. Clinical trial: N/A


 
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