Gold Member Since 2016
Wuhan Hengwo Scien-Tech Co., Ltd.

Adefovir Dipivoxil, Chemical Raw Material, Steroid Hormone manufacturer / supplier in China, offering 99% Good Quality White Powder Adefovir Dipivoxil, Factory Supply Hot Nutrition Powders N-Acetyl-L-Tyrosin, Donepezil Nootropics Powder Donepezil HCl and so on.

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Supplier Homepage Product Food Additives 99% Good Quality White Powder Adefovir Dipivoxil

99% Good Quality White Powder Adefovir Dipivoxil

Purchase Qty.:
(g)
10-99 100+
FOB Unit Price: US $1 US $0.78
Purchase Qty. (g) FOB Unit Price
10-99 US $1
100+ US $0.78
Get Latest Price
Port: Hong Kong, Hong Kong
Production Capacity: 2000 Tons/Year
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: Adefovir dipivoxil
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • Alias: Hepsera; Preveon; Adefovir Pivoxil; Adefovir Depiv
  • Einecs No: 200-001-8
  • Molecular Weight: 501.47
  • Trademark: Fuluobiotech
  • Specification: USD Standard
  • HS Code: 3001200010
  • Powder: Yes
  • Certification: GMP, HSE, ISO 9001
  • State: Solid
  • Product Name: Adefovir Dipivoxil
  • CAS Registry Number: 142340-99-6
  • Molecular Formula: C20h32n5o8p
  • Appearance: White Powder
  • Transport Package: 1 Kg/Foil Bag
  • Origin: Hubei, China
Product Description
99% Good Quality White Powder Adefovir Dipivoxil
 
Product NameAdefovir dipivoxil
AliasHepsera; Preveon; Adefovir pivoxil; Adefovir depivoxil  
CAS Registry Number142340-99-6
Einecs No200-001-8
Molecular FormulaC20H32N5O8P
Molecular Weight501.47
Purity 98%
GradePharmaceutical Grade
Appearancewhite crytalline powder



Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir.

Indication
For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

Pharmacodynamics
Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.

Mechanism of action
Adefovir dipivoxil is a prodrug of adefovir. Adefovir is an acyclic nucleotide analog of adenosine monophosphate which is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA. The inhibition constant (Ki) for adefovir diphosphate for HBV DNA polymerase was 0.1 μM. Adefovir diphosphate is a weak inhibitor of human DNA polymerases α and γ with Ki values of 1.18 μM and 0.97μM, respectively.



 
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