Antihypertensive for Hypertension Treatment CAS 124750-99-8 Losartan Potassium
|FOB Unit Price:||US $1 US $0.78|
|Purchase Qty. (g)||FOB Unit Price|
|Production Capacity:||2 Tons/Year|
|Transport Package:||1 Kg/Foil Bag|
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- Model NO.: Losartan potassium
- Customized: Customized
- Suitable for: Adult
- Purity: >99%
- Alias: Losartan Potassium
- Einecs No: 200-287-4
- Molecular Weight: 462.01
- Trademark: YC
- Origin: Hubei, China
- Powder: Yes
- Certification: GMP, HSE, ISO 9001
- State: Solid
- Product Name: Losartan Potassium
- CAS Registry Number: 124750-99-8
- Molecular Formula: C22h23clkn6o
- Appearance: White Powder
- Specification: USD Standard
- HS Code: 3001200010
Product Name: Losartan potassium
Synonyms: 2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL;2-butyl-4-chloro-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol monopotassium salt;2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOLE-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL, POTASSIUM SALT;COZAAR;DUP 753;LOSARTAN MONOPOTASSIUM SALT;LOSARTAN POTASSIUM;LOSARTAN POTASSIUM SALT
Product Categories: Hypertension;Intermediates & Fine Chemicals;Pharmaceuticals;Losartan;APIS;Aromatics;Heterocycles;API Reference Standard;COZAAR;Cardiovascular APIs;API
Mol File: 124750-99-8.mol
Losartan potassium Structure
Chemical Properties White to Off-White Crystalline Powder
Usage A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Usage antihypertensive, AT1 angiotensin II antagonist
Usage Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).
Clinical application of losartan potassium is a new type of non peptide angiotensin II receptor (AT1) antagonist, in vivo metabolism generated EXP3174 is more durable than activity stronger, TK, losartan and EXP3174 respectively with a half-life of 2.2 hours and 6.7 hours. Losartan potassium has a good antihypertensive effect and protects the heart, kidney and brain, reverses the myocardial and vascular wall hypertrophy, excrete sodium and diuresis, and promotes the excretion of uric acid. The incidence of adverse events was low and the patients were well tolerated. The major domestic manufacturers is Hangzhou moshadong Pharmaceutical Co. Ltd, Zhejiang Huahai pharmaceutical Limited by Share Ltd and Yangtze River Pharmaceutical Group Sichuan Hai Rong pharmaceutical and clinical application of the current known as follows:
1., the treatment of primary hypertension can be used alone or in combination with other antihypertensive agents (such as diuretics).
2. treatment of heart failure can be used alone or in combination with cardiac drugs and diuretics.
3. stroke prevention in hypertensive patients with left ventricular hypertrophy.
4. is used to slow down the progression of kidney disease in type 2 diabetic patients with kidney disease and hypertension.
Usage Hangzhou moshadong Pharmaceutical Co. Ltd. the production of Losartan Potassium Tablets for the following usage and dosage in the treatment of primary hypertension:
Drug specifications: 50mg*7 tablets
Other name: colea, losartan, Cozaar, losartan, losartan potassium, losartan, losartan, losartan potassium
Can be used with other antihypertensive drugs.
Can be taken with food at the same time.
Patients with reduced blood volume may experience hypotension when they begin to apply, reducing the initial dosage to 10mg.
For most patients, the starting and maintenance doses are usually 50mg per day. The maximal antihypertensive effect can be achieved by 3 to 6 weeks of treatment.
In some patients, the increase in dosage to once daily 100mg can produce further antihypertensive effects.
For patients with insufficient vascular capacity (for example, patients treated with high-dose diuretics), the starting dose of 25mg per day may be considered.
For elderly patients or patients with renal impairment, including dialysis patients, the starting dose should not be adjusted. Patients with a history of liver function impairment should be considered for lower doses.
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