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Wuhan Hengwo Scien-Tech Co., Ltd.

Camptothecin, Plant Extract, Camptothecine manufacturer / supplier in China, offering Plant Extract Camptothecin Pharmaceutical Camptothecin CAS 7689-03-4, Factory Supply Hot Nutrition Powders N-Acetyl-L-Tyrosin, Donepezil Nootropics Powder Donepezil HCl and so on.

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Supplier Homepage Product Plant Extract Plant Extract Camptothecin Pharmaceutical Camptothecin CAS 7689-03-4

Plant Extract Camptothecin Pharmaceutical Camptothecin CAS 7689-03-4

Purchase Qty.:
(gram)
10-19 20-49 50-99 100+
FOB Unit Price: US $2 US $5 US $8 US $10
Purchase Qty. (gram) FOB Unit Price
10-19 US $2
20-49 US $5
50-99 US $8
100+ US $10
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Port: Hong Kong, Hong Kong
Production Capacity: 5000kg/Month
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: CAS 7689-03-4
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • CAS: 7689-03-4
  • MW: 349.3849
  • Trademark: Biopharmchem
  • Specification: Pharmaceutical Grade
  • HS Code: 2932290090
  • Powder: Yes
  • Certification: GMP, HSE, ISO 9001, USP, BP
  • State: Solid
  • Product Name: Camptothecin
  • Mf: C16h23n5o4
  • Water Solubility: Insoluble
  • Transport Package: as Requires
  • Origin: China
Product Description

            Plant Extract Camptothecin pharmaceutical Camptothecin CAS 7689-03-4
 
Product nameCamptothecin,CPT,Hydroxyamptothecin
English nameCamptothecine
CAS7689-03-4
MFC16H23N5O4
MW349.3849
Purity>98%
StorageDesiccate at +4
Melting point260°C
Water solubilityinsoluble
UsageIt is used to treat stomach, bowel, chronic myeloid and acute leukemia.


An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. 

Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine.                    
                                                                      
CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Camptothecin is believed to be a potent topoisomerase inhibitor that interferes with the essential function of topoisomerase in DNA replication.

Because of these disadvantages, synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.

Camptothecin is an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI)

Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay.

Camptothecin

Camptothecin, a Chinese tree derivative, affects topoisomerase I, allowing DNA cleavage, but inhibiting subsequent ligation, and resulting in DNA strand breaks. The use of camptothecin systemically is also limited by significant toxicity (Slichenmyer et al., 1993). Camptothecin does show potent antiglioma activity in vitro, making it another popular candidate for polymer delivery. Sodium camptothecin loaded onto 50% EVAc polymers was tested in the 9L gliosarcoma rat model, and resulted in a significant increase in survival. Median survival was 19 days in control rats and more than 120 days with camptothecin polymers (p<0.001). Direct intratumoral injection of the camptothecin without polymer showed no increase in survival compared with controls.

Studies incorporating camptothecin into 50% PCPP:SA polymers for the treatment of 9L gliosarcoma in rats showed safety and efficacy, with a median survival of 69 days in animals treated with camptothecin and 17 days in controls (Storm et al., 2002). Administration of intracranial camptothecin by polymer under similar conditions, with the addition of systemic BCNU, showed a significant increase in survival compared with camptothecin alone (Storm et al., 2004).
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