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Wuhan Hengwo Scien-Tech Co., Ltd.

Galantamine Hydrobromide, Chemical Raw Material, Steroid Hormone manufacturer / supplier in China, offering Nootropics Powder Galantamine Hydrobromide CAS 1953-04-4, Oral Tren Prohormone Powders Trendione Trenavar, Female Hormone Estrogen Steroids Estradiol and so on.

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Nootropics Powder Galantamine Hydrobromide CAS 1953-04-4

Purchase Qty.:
10-99 100+
FOB Unit Price: US $1 US $0.78
Purchase Qty. (g) FOB Unit Price
10-99 US $1
100+ US $0.78
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Production Capacity: 2 Tons/Year
Transport Package: 1 Kg/Foil Bag
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: Galantamine Hydrobromide
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • Alias: Galantamine Hydrobromide
  • Einecs No: 217-780-5
  • Molecular Weight: 368.27
  • Trademark: YC
  • Origin: Hubei, China
  • Powder: Yes
  • Certification: GMP, HSE, ISO 9001
  • State: Solid
  • Product Name: Galantamine Hydrobromide
  • CAS Registry Number: 1953-04-4
  • Molecular Formula: C17h22brno3
  • Appearance: White Powder
  • Specification: USD Standard
  • HS Code: 3001200010
Product Description
Nootropics Powder Galantamine HydrobromideCAS 1953-04-4
Product NameGalantamine Hydrobromide
AliasGalantamine Hydrobromide
CAS Registry Number1953-04-4
Einecs No217-780-5
Molecular FormulaC17H22BrNO3
Molecular Weight 368.27
Appearancewhite powder

Product Name:    Galantamine Hydrobromide
CAS:    1953-04-4
MF:    C17H22BrNO3
MW:    368.27
EINECS:    217-780-5
Product Categories:    Alkaloids;Alkaloids (Others);Biochemistry;Functional Products;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Acetylcholine receptor;API;Chiral Reagents;Reminyl;Other APIs;Pharmaceutical intermediates
Mol File:    1953-04-4.mol
Galantamine Hydrobromide Structure
Outline    Galantamine hydrobromide also called as 11-methyl-3-methoxy-4a, 5, 9, 10, 11, 12-hexahydro-6H-benzene and furan [3a, 3, 2-ef] [2] benzazepine-6-ol hydrobromide, is an alkaloid isolated from Lycoris plants. In the 1960 s, China had first successfully isolated it from domestic Medicago Lycoris and Lycoris radiata, and had recorded into the Chinese Pharmacopoeia in 1977. The hydrobromide salt is white crystalline powder and is odorless with bitter taste. It is soluble in water, slightly soluble in ethanol but insoluble in chloroform, acetone, and ether. The absorption coefficient (50 ug in 1 ml of water): at 289nm wavelength, it has an absorption coefficient of 79.6~86.2. It is mainly applied to myasthenia gravis, poliomyelitis sequelae and resting stage as well as being used for the treatment of children with cerebral paralysis, polyneuritis, radiculitis and sensory motor disorders caused by nerve disorders or trauma. It is clinically also used for the treatment of Alzheimer's disease as well as treatment of dementia and memory disorders caused by the organic disease of the brain with significant therapeutic effect. 
Galantamine belongs to the second generation of acetylcholinesterase inhibitor drugs with its pharmaceutical composition being same as the extracted alkaloids of the European Mountain narcissus bulb. This kind of herbal medicine has already had a history of 30 years of clinical application in some countries and regions for the treatment of reversal neuromuscular blockade, myasthenia gravis, and children with cerebral palsy psychosis.
Cholinesterase inhibitors    Galantamine hydrobromide is the hydrobromide salt of galantamine and is a cholinesterase inhibitor can be extracted from Amaryllidaceae Lycoris plant. The III-phase clinical trials in the United Kingdom in 1998 have showed that this drug had dual mechanism of action of both inhibiting acetylcholinesterase and regulating nicotinic receptors. Therefore, galantamine can improve the cognitive abilities of Alzheimer's patients and has been already applied as the drug of the treatment of mild to severe Alzheimer's disease (AD) drugs and has entered into market in EC countries. "Chinese Pharmacopoeia" has included the both the raw material and injection of galantamine hydrobromide. It is clinically mainly used for the treatment of poliomyelitis (polio) sequelae, muscular dystrophy and myasthenia gravis. It can be used to substitute neostigmine methyl-sulfate for antagonism of tubocurarine but with weak performance with the usage amount being ten times as high as the usage amount of neostigmine methyl-sulfate. Intravenous injection of 0.5 mg/kg of galantamine hydrobromide can quickly reverse the central anticholinergic effects caused through injection of scopolamine hydrobromide. It can also be used for treating children cerebral palsy, traumatic sensorimotor disorders, multiple neuritis and radiculitis.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Physical and Chemical Properties    It is white crystalline powder and is odorless with bitter taste. It is soluble in water, slightly soluble in ethanol and insoluble in acetone, chloroform, ether and benzene.
Contraindications    Patients being allergic to galantamine hydrobromide are prohibited 
Galantamine, as a kind of cholinesterase inhibitors is prohibited during the process of anesthesia 
Patients with angina and bradycardia are disabled
Patients with severe asthma or pulmonary dysfunction are disabled
Patients of severe liver damage were banned
Patients of severe kidney damage were disabled
Patients with mechanical obstruction are disabled
Uses    It can be used for the treatment of neurological diseases and trauma-induced movement disorders, multiple neuritis, and radiculitis.
Cholinesterase inhibitors can reverse the process of scopolamine-induced amnesia.
Chemical Properties    White to Off-White Powder
Usage    A selective acetylcholinesterase inhibitor. A therapeutic agent for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism.
Usage    Alzheimer treatment;Cholinesterase inhibitor
Usage    anticholinesterase, analgesic, antiAlzheimer
Biological Activity    Long-acting, centrally active acetylcholinesterase inhibitor (IC 50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β -amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Company Profile

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