CAS 65-28-1 Factory Supply Pharmaceutical Intermediate Phentolamine Mesilate
|Product Name||Phentolamine Mesilate|
|Alias||Phentolamine methanesulfonate; OraVerse; Regitine mesylate|
|CAS Registry Number||65-28-1|
|Appearance||white crytalline powder|
Phentolamine mesylate is a nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
Phentolamine Mesylate is the mesylate salt of a synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells.