Gold Member Since 2016
Wuhan Hengwo Scien-Tech Co., Ltd.

Axitinib, Anticancer, Cancer Therapy Supplement manufacturer / supplier in China, offering Cancer Therapy Supplement Axitinib Powder for Anticancer, Factory Supply Hot Nutrition Powders N-Acetyl-L-Tyrosin, Donepezil Nootropics Powder Donepezil HCl and so on.

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Cancer Therapy Supplement Axitinib Powder for Anticancer

Purchase Qty.:
(Gram)
10-19 20-49 50+
FOB Unit Price: US $1 US $0.8 US $0.5
Purchase Qty. (Gram) FOB Unit Price
10-19 US $1
20-49 US $0.8
50+ US $0.5
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Port: Hong Kong, Hong Kong
Production Capacity: 5000kg/Month
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: CAS 319460-85-0
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • CAS: 319460-85-0
  • MW: 386.4695
  • Transport Package: as Requires
  • Origin: China
  • Powder: Yes
  • Certification: GMP, HSE, ISO 9001, USP, BP
  • State: Solid
  • Product Name: Axitinib, Inlyta, Benzamide
  • Mf: C22h18n4OS
  • Trademark: Biopharmchem
  • Specification: Pharmaceutical Grade
  • HS Code: 3001200020
Product Description

               Cancer Therapy supplement Axitinib powder for anticancer

Product name:Axitinib,INLYTA,benzamide
CAS: 319460-85-0
MF: C22H18N4OS
MW: 386.4695

Drug Type  

Axitinib is a targeted therapy and is a receptor protein-kinase inhibitor. It inhibits the actions of vascular growth factor (VEGF) and is an angiogenesis inhibitor.

Axitinib (AG013736; trade name Inlyta) is a small molecule tyrosine kinase inhibitor developed by Pfizer. It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models and has shown partial responses in clinical trials with renal cell carcinoma (RCC) and several other tumour types.

Advantage

Axitinib is a Kinase Inhibitor. The mechanism of action of axitinib is as a Receptor Tyrosine Kinase Inhibitor.

AG-013736 is an orally bioavailable tyrosine kinase inhibitor. Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGF), thereby exerting an anti-angiogenic effect.

Axitinib is an oral tyrosine kinase inhibitor selective for vascular endothelial growth factor (VEGF) receptors -1, -2 and -3 that is used in the therapy of advanced renal cell carcinoma. Axitinib therapy is commonly associated with transient elevations in serum aminotransferase that are generally mild and asymptomatic. Axitinib has yet to be linked to instances of clinically apparent acute liver injury.

Used in kidney cell cancer and investigated for use/treatment in pancreatic and thyroid cancer.

Contraindications

The only contraindication to axitinib is hypersensitivity to axitinib.

Cautions include:
Hypertension
Thromboembolic (both venous and arterial) events
Haemorrhagic events (including cerebral haemorrhage)
GI perforations and fistula
Thyroid function, it is advised that thyroid function is measured initially and then periodically during treatment with axitinib.
Stop treatment 24 hours prior to surgery due to potential clotting changes
Proteinuria, it is advised that proteinuria is monitored initially and then periodically during therapy
Elevated liver enzymes reported, it is advised that AST, ALT and bilirubin are regularly monitored during treatment with axitinib
Moderate hepatic impairment requires dose reduction

Side effects

Diarrhea, hypertension, fatigue, decreased appetite, nausea, dysphonia, hand-foot syndrome, weight decreased, vomiting, asthenia, and constipation are the most common side effects occurring in more than 20% of patients.  

Recommended Dosing

The recommended starting oral dose of INLYTA is 5 mg twice daily. Administer INLYTA doses approximately 12 hours apart with or without food . INLYTA should be swallowed whole with a glass of water.

If the patient vomits or misses a dose, an additional dose should not be taken. The next prescribed dose should be taken at the usual time.
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