Gold Member Since 2016
Wuhan Hengwo Scien-Tech Co., Ltd.

Nootropics Powder Donepezil HCl, Chemical Raw Material, Steroid Hormone manufacturer / supplier in China, offering Donepezil Nootropics Powder Donepezil HCl, Natural Plant 99% Min Extract Silymarin CAS 65666-07-1, High Purity Anabolic Steroid Hormone Powder Drostanolone Propionate Masteron and so on.

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Donepezil Nootropics Powder Donepezil HCl

Purchase Qty.:
(g)
10-99 100+
FOB Unit Price: US $1 US $0.78
Purchase Qty. (g) FOB Unit Price
10-99 US $1
100+ US $0.78
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Port: Hong Kong, Hong Kong
Production Capacity: 2000 Tons/Year
Payment Terms: T/T, Western Union, Money Gram, Bitcoin

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Basic Info
  • Model NO.: donepezil
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • Alias: Donepezil Hydrochloride
  • Einecs No: C24h30clno3
  • Molecular Weight: 415.95
  • Trademark: Biopharmchem
  • Specification: USD Standard
  • HS Code: 3001200010
  • Powder: Yes
  • Certification: GMP, HSE, ISO 9001
  • State: Solid
  • Product Name: Donepezil
  • CAS Registry Number:  110119-84-1
  • Molecular Formula: C24h30clno3
  • Appearance: White Powder
  • Transport Package: 1 Kg/Foil Bag
  • Origin: Hubei, China
Product Description
Donepezil Nootropics Powder Donepezil HCl


Product name:Donepezil hydrochloride
Synonyms:Akos 226-31;E-2020;Donepezil hcl;Aricept;Donepezilhcl120011-70-3/;Donepezil (donepezil hydrochloride);2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride;Donepezil hydrochloride
Cas:110119-84-1
Mf:C24h30clno3
Mw:415.95
Einecs:
Product categories:Api
Mol file:110119-84-1.Mol
Donepezil hydrochloride structure
The treatment for alzheimer's disease drug donepezil hydrochloride is a kind of therapeutic drugs for alzheimer's disease, which belongs to the second generation of acetylcholinesterase (che) inhibitors for the treatment of mild or moderate alzheimer's disease patients, compared with the same kind of drugs with low incidence of adverse reactions and efficacy obvious characteristics, is the only way to reach the u.S.Food and drug drug administration of dementia treatment guidelines, is the only one at the same time by the united states and britain fda mca approved drug for the treatment of mild to moderate alzheimer's disease.
At present, the pathogenesis of cognitive impairment in alzheimer's disease is related to the dysfunction of cholinergic neurotransmission.Donepezil can play a therapeutic role by enhancing the function of cholinergic nerves.It reversibly inhibits the hydrolysis of acetylcholinesterase to acetylcholine, thereby increasing the concentration of acetylcholine in the receptor site.According to the above mechanism, with the progress of the disease, the functional integrity of cholinergic neurons gradually reduced, the role of donepezil may be weakened.There is no evidence that donepezil can alter the underlying course of dementia.

Toxic reproductive toxicity:Rats were given 10mg/kg/ days (by body surface area conversion, about 8 times the maximum recommended dose), fertility is not affected.The rats and rabbits pregnancy were given donepezil was 16 and 10mg/kg/ days (according to the surface area of the conversion, respectively with recommended maximum dose of 13 and 16 times), there was no obvious teratogenic effect.Another test in rats from gestational day seventeenth to twentieth days after delivery for donepezil in 10mg/kg/ days (according to the surface area of the conversion, is about 8 times the maximum recommended dose), a slight increase in stillbirths, 4 days postpartum uchiko generation survival rate decreased slightly.
Genotoxicity:No mutagenicity was observed in the ames bacterial reverse mutation test.In the chinese hamster lung cell chromosome aberration test, we can see that the production of donepezil is induced.The effect of donepezil in the micronucleus test of mice.Carcinogenicity:Currently there is no carcinogenicity study of donepezil.
Note 1.Highly sensitive to donepezil or piperidine derivatives.
2, heart disease, asthma or obstructive pulmonary disease patients have an impact, but also can increase the risk of gastrointestinal ulcer.
3, the role of cholinergic may cause urinary retention and convulsions (may be related to the original disease), medication should be observed.
4, and succinylcholine muscle relaxants, anticholinergic drugs have antagonistic effect, it can not be used.
 
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